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The curvature of each version's straps are designed to fit optimally on each sex. The Women's Setout Backpack's straps are curved for narrower frames with a higher-placed chest strap (so that it won't cut across your breasts). The Men's Setout Backpack's straps are curved to fit optimally on broader shoulders.
Left: Women's Setout Backpack straps. Right: Men's Setout Backpack Straps.
The Women's Setout Backpack's straps have a layer of closed-cell foam for structure and durability and a layer of soft, squishy, open-cell foam for cushiness. The straps feel springy and squishy on first touch, and feel comfy as soon as you put the bag on for the first time.
The Men's Setout Backpack's straps are made from injection-molded, closed-cell EVA foam. Picture the dense, slightly squishy stuff found in the bottom of running shoes. Closed-cell foam is a slightly rigid, highly durable type of foam that breaks in over time to get even more comfortable. It’s not springy like open-cell foam and won’t flatten over time, but it’s also not as cushy.
The Men's Setout Backpack has a slightly larger hip belt, and the Women's Setout Backpack's is slightly smaller. The Women's Setout Backpack's hip belt will tighten tighter than the men's version. Both hip belts are highly adjustable to fit a large range of sizes and include pockets for your cell phone, boarding passes, and anything else you might want to quickly access en route.
The rest of the backpack, from the fabric to compartments to packing space, is identical. There is nothing inherently masculine or feminine in the expression of either backpack -- the difference is in ergonomics and physiology, not aesthetics.